Structure of PDB 4r09 Chain D

Receptor sequence
>4r09D (length=746) Species: 9606 (Homo sapiens) [Search protein sequence]
RSYPCDEKKQVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQ
GLQNLTKINLNHNPNNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPE
SLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGV
FETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLI
NLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSS
TSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSF
NYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNL
STINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLDFEFDPHSNFYHF
TRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQV
LSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRI
AGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRL
DILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELH
INDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLS
HNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELH
GNPFECTCDIGDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVS
3D structure
PDB4r09 Toll-like receptor 8 senses degradation products of single-stranded RNA.
ChainD
Resolution2.62 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 URI D D543 D545 V573 D473 D475 V503
BS02 URI D Y348 G351 Y353 V378 F405 R429 Y302 G305 Y307 V332 F359 R383
BS03 06S D Y291 I341 D343 H373 R375 H469 T471 L474 Y245 I295 D297 H327 R329 H399 T401 L404
BS04 UPT D P264 F320 F346 R375 F467 Y468 P218 F274 F300 R329 F397 Y398
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4r09, PDBe:4r09, PDBj:4r09
PDBsum4r09
PubMed25599397
UniProtQ9NR97|TLR8_HUMAN Toll-like receptor 8 (Gene Name=TLR8)

[Back to BioLiP]