Structure of PDB 4qtu Chain D

Receptor sequence
>4qtuD (length=179) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
EAHKYTGSTRVQHIQAKMTLRALELLNLQPCSFILDIGCGSGLSGEILTQ
EGDHVWCGLDISPSMLATGLSRELEGDLMLQDMGTGIPFRAGSFDAAISI
SAIQWLCNDPKQRLMRFFNTLYAALKKGGKFVAQFYPKNDDQVDDILQSA
KVAGFSGGLVVDDPESKKNKKYYLVLSSG
3D structure
PDB4qtu Structural and functional studies of Bud23-Trm112 reveal 18S rRNA N7-G1575 methylation occurs on late 40S precursor ribosomes.
ChainD
Resolution2.124 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.309: 18S rRNA (guanine(1575)-N(7))-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAM D Y22 Q32 G55 C56 G57 S61 D77 I78 D99 M100 I117 S118 W122 Y5 Q15 G38 C39 G40 S44 D60 I61 D82 M83 I100 S101 W105
Gene Ontology
Molecular Function
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0016435 rRNA (guanine) methyltransferase activity
Biological Process
GO:0070476 rRNA (guanine-N7)-methylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4qtu, PDBe:4qtu, PDBj:4qtu
PDBsum4qtu
PubMed25489090
UniProtP25627|BUD23_YEAST 18S rRNA (guanine(1575)-N(7))-methyltransferase (Gene Name=BUD23)

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