Structure of PDB 4qii Chain D

Receptor sequence
>4qiiD (length=299) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
SDNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHT
VDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGY
QYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSL
HVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFL
GRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAF
NLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF
3D structure
PDB4qii Ligand-dependent active-site closure revealed in the crystal structure of Mycobacterium tuberculosis MenB complexed with product analogues
ChainD
Resolution1.64 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287
Catalytic site (residue number reindexed from 1) G90 R95 Y100 R115 H120 G146 S149 D170 S175 D177 G178 A264 Y272
Enzyme Commision number 4.1.3.36: 1,4-dihydroxy-2-naphthoyl-CoA synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2NE D F299 K302 F284 K287
BS02 2NE D V57 R58 A60 S103 G104 G105 D106 Q107 Y115 W157 A159 G161 T184 D185 S190 V42 R43 A45 S88 G89 G90 D91 Q92 Y100 W142 A144 G146 T169 D170 S175
Gene Ontology
Molecular Function
GO:0008935 1,4-dihydroxy-2-naphthoyl-CoA synthase activity
GO:0016829 lyase activity
Biological Process
GO:0009234 menaquinone biosynthetic process
GO:0034214 protein hexamerization
Cellular Component
GO:0005886 plasma membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4qii, PDBe:4qii, PDBj:4qii
PDBsum4qii
PubMed25372686
UniProtP9WNP5|MENB_MYCTU 1,4-dihydroxy-2-naphthoyl-CoA synthase (Gene Name=menB)

[Back to BioLiP]