Structure of PDB 4qfy Chain D

Receptor sequence

>4qfyD (length=481) Species: 9606 (Homo sapiens) [Search protein sequence]

DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASH
NRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGP
FSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPE
EDICFIKEQIVGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFAR
DCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNS
LHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEA
YTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKI
KREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHV
SFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQY
FVQWCADRNFTKPQDGDVIAPLITPQKKEWN

3D structure

PDB

4qfy Structural Basis of Allosteric Activation of Sterile alpha Motif and Histidine-Aspartate Domain-containing Protein 1 (SAMHD1) by Nucleoside Triphosphates.

Chain

Resolution

2.1 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	DGT	D	K116 I118 D137 R145	K4 I6 D25 R33
BS02	DGT	D	Y155 V156 V378 R451 K455	Y43 V44 V260 R333 K337
BS03	DGT	D	V156 F157 R372 H376 K377	V44 F45 R254 H258 K259
BS04	DGT	D	V117 N119	V5 N7
BS05	DGT	D	R333 R352 K354 K523	R215 R234 K236 K405
BS06	DCP	D	L150 R164 R206 H210 H215 H233 K312 Y315 D319 R366 Y374	L38 R52 R94 H98 H103 H121 K194 Y197 D201 R248 Y256

External links

PDB	RCSB:4qfy, PDBe:4qfy, PDBj:4qfy
PDBsum	4qfy
PubMed	25288794
UniProt	Q9Y3Z3\|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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