Structure of PDB 4pnq Chain D

Receptor sequence
>4pnqD (length=190) Species: 9606 (Homo sapiens) [Search protein sequence]
EFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRR
KEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAE
NSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAM
KMAHSPPGHHSVTGRLAEYVIYRGEQAYPEYLITYQIMRP
3D structure
PDB4pnq Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.
ChainD
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D C1081 H1084 C1089 C1092 C118 H121 C126 C129
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4pnq, PDBe:4pnq, PDBj:4pnq
PDBsum4pnq
PubMed25286857
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

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