Structure of PDB 4p75 Chain D

Receptor sequence
>4p75D (length=243) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence]
LAAERIDVTLPGRGQLSGGLHPVTRTLERIEQCFSRIGYEVAEGPEVEDD
YHNFEALNIPGHHPARAMHDTFYFNANMLLRTHTSPVQVRTMESQQPPIR
IVCPGRVYRCDSDLTHSPMFHQVEGLLVDEGVSFADLKGTIEEFLRAFFE
KQLEVRFRPSFFPFTEPSAEVDIQCVICSGGWLEVMGCGMVHPNVLRMSN
IDPEKFQGFAFGMGAERLAMLRYGVNDLRLFFDNDLRFLGQFR
3D structure
PDB4p75 The role of a novel auxiliary pocket in bacterial phenylalanyl-tRNA synthetase druggability.
ChainD
Resolution2.96 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H76 H90 R116 Q129 T172 A226
Catalytic site (residue number reindexed from 1) H69 H83 R109 Q122 T165 A210
Enzyme Commision number 6.1.1.20: phenylalanine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2NM D L64 S92 Q95 E131 F171 G203 C204 A226 G228 L57 S85 Q88 E124 F164 G187 C188 A210 G212
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004826 phenylalanine-tRNA ligase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0006432 phenylalanyl-tRNA aminoacylation
GO:0043039 tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4p75, PDBe:4p75, PDBj:4p75
PDBsum4p75
PubMed24936059
UniProtQ9I0A3|SYFA_PSEAE Phenylalanine--tRNA ligase alpha subunit (Gene Name=pheS)

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