Structure of PDB 4p72 Chain D

Receptor sequence
>4p72D (length=244) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence]
LAAERIDVTLPGRGQLSGGLHPVTRTLERIEQCFSRIGYEVAEGPEVEDD
YHNFEALNIPGHHPARAMHDTFYFNANMLLRTHTSPVQVRTMESQQPPIR
IVCPGRVYRCDSDLTHSPMFHQVEGLLVDEGVSFADLKGTIEEFLRAFFE
KQLEVRFRPSFFPFTEPSAEVDIQCVICSGNGWLEVMGCGMVHPNVLRMS
NIDPEKFQGFAFGMGAERLAMLRYGVNDLRLFFDNDLRFLGQFR
3D structure
PDB4p72 The role of a novel auxiliary pocket in bacterial phenylalanyl-tRNA synthetase druggability.
ChainD
Resolution2.62 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H76 H90 R116 Q129 T172 A226
Catalytic site (residue number reindexed from 1) H69 H83 R109 Q122 T165 A211
Enzyme Commision number 6.1.1.20: phenylalanine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2NL D L64 E131 F171 T172 G203 C204 A226 F227 G228 M229 L57 E124 F164 T165 G188 C189 A211 F212 G213 M214
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004826 phenylalanine-tRNA ligase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0006432 phenylalanyl-tRNA aminoacylation
GO:0043039 tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4p72, PDBe:4p72, PDBj:4p72
PDBsum4p72
PubMed24936059
UniProtQ9I0A3|SYFA_PSEAE Phenylalanine--tRNA ligase alpha subunit (Gene Name=pheS)

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