Structure of PDB 4p2v Chain D

Receptor sequence
>4p2vD (length=281) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
DGKDFRTDQPQKNIPFTLKGCGALDWGMQSRLSRIFNPKTGKTVMLAFDH
GYFQGPTTGLERIDINIAPLFEHADVLMCTRGILRSVVPPATNRPVVLRA
SGANSILAELSNEAVALSMDDAVRLNSCAVAAQVYIGSEYEHQSIKNIIQ
LVDAGMKVGMPTMAVTGVGKDMVRDQRYFSLATRIAAEMGAQIIATYYVE
KGFERIVAGCPVPIVIAGGKKLPEREALEMCWQAIDQGASGVDMGRNIFQ
SDHPVAMMKAVQAVVHHNETADRAYELYLSE
3D structure
PDB4p2v LsrF, a coenzyme A-dependent thiolase, catalyzes the terminal step in processing the quorum sensing signal autoinducer-2.
ChainD
Resolution2.51 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.245: 3-hydroxy-5-phosphooxypentane-2,4-dione thiolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 26T D H58 Y60 F61 Q141 G226 G253 R254 H50 Y52 F53 Q133 G218 G245 R246
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004332 fructose-bisphosphate aldolase activity
GO:0016740 transferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0016829 lyase activity
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
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Cellular Component
External links
PDB RCSB:4p2v, PDBe:4p2v, PDBj:4p2v
PDBsum4p2v
PubMed25225400
UniProtP76143|LSRF_ECOLI 3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase (Gene Name=lsrF)

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