Structure of PDB 4obv Chain D

Receptor sequence
>4obvD (length=469) Species: 411470 (Mediterraneibacter gnavus ATCC 29149) [Search protein sequence]
TEYILNSTQLEEAIKSFVHDFCAEKHEIHDQPVVVEAKEHQEDKIKQIKI
PEKGRPVNEVVSEMMNEVYRYRGDANHPRFFSFVPGPASSVSWLGDIMTS
AYNIHAGGSKLAPMVNCIEQEVLKWLAKQVGFTENPGGVFVSGGSMANIT
ALTAARDNKLTDINLHLGTAYISDQTHSSVAKGLRIIGITDSRIRRIPTN
SHFQMDTTKLEEAIETDKKSGYIPFVVIGTAGTTNTGSIDPLTEISALCK
KHDMWFHIDGAYGASVLLSPKYKSLLTGTGLADSISWDAHKWLFQTYGCA
MVLVKDIRNLFHSFHVNPEYLKDLEDNVNTWDIGMELTRPARGLKLWLTL
QVLGSDLIGSAIEHGFQLAVWAEEALNPKKDWEIVSPAQMAMINFRYAPK
DLTKEEQDILNEKISHRILESGYAAIFTTVLNGKTVLRICAIHPEATQED
MQHTIDLLDQYGREIYTEM
3D structure
PDB4obv Discovery and Characterization of Gut Microbiota Decarboxylases that Can Produce the Neurotransmitter Tryptamine.
ChainD
Resolution2.84 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.1.105: L-tryptophan decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2SU D P102 A103 S104 S105 F309 P462 E463 P87 A88 S89 S90 F294 P444 E445 PDBbind-CN: -logKd/Ki=0.75,Ki=178mM
BS02 3SO D F98 V99 S160 H192 T249 D274 A276 D303 K306 F83 V84 S145 H177 T234 D259 A261 D288 K291
BS03 3SO D H120 L339 T356 H105 L324 T338
Gene Ontology
Molecular Function
GO:0004058 aromatic-L-amino-acid decarboxylase activity
GO:0016830 carbon-carbon lyase activity
GO:0016831 carboxy-lyase activity
GO:0030170 pyridoxal phosphate binding
GO:0036469 L-tryptophan decarboxylase activity
Biological Process
GO:0006520 amino acid metabolic process
GO:0006568 tryptophan metabolic process
GO:0019752 carboxylic acid metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4obv, PDBe:4obv, PDBj:4obv
PDBsum4obv
PubMed25263219
UniProtA7B1V0|TRPDC_MEDG7 Tryptophan decarboxylase (Gene Name=RUMGNA_01526)

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