Structure of PDB 4oav Chain D

Receptor sequence

>4oavD (length=674) Species: 9606 (Homo sapiens) [Search protein sequence]

NHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIV
ELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYG
FTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDA
AEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLL
LDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKT
ALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSHGA
KEWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGF
YEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVC
VTLCEQTLEACLDVNEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQN
ILIDSKKAAHLADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFE
DLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWE
SRYRTLRNVGNESDIKTRKSESEILRLLQPGPSEHSKSFDKWTTKINECV
MKKMNKFYEKRGNFYQNTVGDLLKFIRNLGENIDEMKLKIGDPSLYFQKT
FPDLVIYVYTKLQNTEYRKHFPQT

3D structure

PDB

4oav Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response.

Chain

Resolution

2.1 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.26.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	D	E55 E56 E57 G58 W60 Q68 K89 N91 Y124 F126 E131 Y135 R155 K166 R203	E30 E31 E32 G33 W35 Q43 K64 N66 Y99 F101 E106 Y110 R130 K141 R178
BS02	rna	D	M306 R309 R310 Y312 Y354 R355 R427	M281 R284 R285 Y287 Y321 R322 R394
BS03	ACP	D	A372 T374 S375 I379 A390 K392 R400 C437 T440 Q489 L492 D503 D505	A339 T341 S342 I346 A357 K359 R367 C404 T407 Q449 L452 D463 D465
BS04	MG	D	N490 D503	N450 D463
BS05	MG	D	D503 D505	D463 D465
BS06	PUP	D	T607 F647 Y648 R651 N668 N672	T567 F607 Y608 R611 N628 N632

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0004519	endonuclease activity
GO:0004521	RNA endonuclease activity
GO:0004540	RNA nuclease activity
GO:0004672	protein kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019843	rRNA binding
GO:0043021	ribonucleoprotein complex binding
GO:0046872	metal ion binding

	Biological Process
GO:0006364	rRNA processing
GO:0006396	RNA processing
GO:0006397	mRNA processing
GO:0006468	protein phosphorylation
GO:0043488	regulation of mRNA stability
GO:0045071	negative regulation of viral genome replication
GO:0045444	fat cell differentiation
GO:0045944	positive regulation of transcription by RNA polymerase II
GO:0046326	positive regulation of D-glucose import
GO:0051607	defense response to virus

	Cellular Component
GO:0005575	cellular_component
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0005829	cytosol
GO:0016363	nuclear matrix

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:4oav, PDBe:4oav, PDBj:4oav
PDBsum	4oav
PubMed	24578532
UniProt	Q05823\|RN5A_HUMAN 2-5A-dependent ribonuclease (Gene Name=RNASEL)

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