Structure of PDB 4o76 Chain D

Receptor sequence
>4o76D (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB4o76 Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors.
ChainD
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1M3 D D145 L148 D104 L107 MOAD: ic50=0.13uM
BindingDB: IC50=130nM,Kd=123nM
BS02 1M3 D W81 P82 F83 L92 L94 N140 W40 P41 F42 L51 L53 N99 MOAD: ic50=0.13uM
BindingDB: IC50=130nM,Kd=123nM
External links
PDB RCSB:4o76, PDBe:4o76, PDBj:4o76
PDBsum4o76
PubMed24568369
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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