Structure of PDB 4o1p Chain D

Receptor sequence
>4o1pD (length=668) Species: 9823 (Sus scrofa) [Search protein sequence]
SLEEMLTQAVQEADIEQVRQLLERGADANFQEEEWGWSPLHSAVQMDSED
LVALLLKHGADPCLRKRNGATPFIIAGITGNVRLLQLLLPNVEDVNECDV
NGFTAFMEAAVYGRVEALRFLYENGADVNMHRKTKQDQERIRKGGATALM
DAAEKGHVGVVTILLHAMKAEVDARDNMGRNALVYALLNPDDGKAKAITR
LLLDHGADVNVRGEGSKTPLILAVERKNLDLVQMLLEQEQIEVNDTDREG
KTALLLAVELRLEEIAKLLCHRGASTNCGDLVAIARRNYDSDLVKFLRLH
KNWKPQSSRWGEALKHLHRIWRPMIGKLKIFIDEEYKIADTAEGGIYLGL
YEDQEVAVKRFSEGSTRGQQEVSCLQSSRANDNVVTFYGSESDGSCLHVC
LALCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQ
DLQPQNILIDSKNGTFLADFDKSIKWAEDPQKIKRDLEALGLLVLYVVKK
GDISFETLKNQSFEEVIQGSPDEETRDLIHHLFHPGRLSSLLAHPFFWSW
ESRYRTLRDVGNESDIKTRNQNSRILQLLQPTSFAQWTTKIDSFVMEEMN
AYQDTLGDLLKFIRNLGEHINEQKNKKMKSIIGEPSQYFQEKFPDLVMYV
YTKLQNTEYMKHFPKTHN
3D structure
PDB4o1p Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity.
ChainD
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 25L D R307 R308 Y310 R353 R286 R287 Y289 R322
BS02 ANP D A370 T372 I377 A388 K390 R398 C435 T438 Q486 L489 D500 D502 A339 T341 I346 A357 K359 R367 C404 T407 Q455 L458 D469 D471
BS03 25L D W56 W58 Q66 K87 N122 F124 E129 Y133 R153 K164 W35 W37 Q45 K66 N101 F103 E108 Y112 R132 K143
Gene Ontology
Molecular Function
GO:0004540 RNA nuclease activity
GO:0004672 protein kinase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006397 mRNA processing
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4o1p, PDBe:4o1p, PDBj:4o1p
PDBsum4o1p
PubMed24462203
UniProtA5H025

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