Structure of PDB 4ns3 Chain D

Receptor sequence
>4ns3D (length=544) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
HMDAITQVPVPANEPVHDYAPKSPERTRLRTELASLADHPIDLPHVIGGR
HRMGDGERIDVVQPHRHAARLGTLTNATHADAAAAVEAAMSAKSDWAALP
FDERAAVFLRAADLLAGPWREKIAAATMLGQSKSVYQAEIDAVCELIDFW
RFNVAFARQILEQQPISGPGEWNRIDYRPLDGFVYAITPFNFTSIAGNLP
TAPALMGNTVIWKPSITQTLAAYLTMQLLEAAGLPPGVINLVTGDGFAVS
DVALADPRLAGIHFTGSTATFGHLWQWVGTNIGRYHSYPRLVGETGGKDF
VVAHASARPDVLRTALIRGAFDYQGQKCSAVSRAFIAHSVWQRMGDELLA
KAAELRYGDITDLSNYGGALIDQRAFVKNVDAIERAKGAAAVTVAVGGEY
DDSEGYFVRPTVLLSDDPTDESFVIEYFGPLLSVHVYPDERYEQILDVID
TGSRYALTGAVIADDRQAVLTALDRLRFAAGNFYVNDKPTGAVVGRQPFG
GARGSDTNDKAGSPLNLLRWTSARSIKETFVAATDHIYPHMAVD
3D structure
PDB4ns3 Use of a "silver bullet" to resolve crystal lattice dislocation disorder: A cobalamin complex of Delta (1)-pyrroline-5-carboxylate dehydrogenase from Mycobacterium tuberculosis.
ChainD
Resolution2.38 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N190 K212 E293 C327 E425 A510
Catalytic site (residue number reindexed from 1) N191 K213 E294 C328 E426 A511
Enzyme Commision number 1.2.1.88: L-glutamate gamma-semialdehyde dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B12 D I186 F246 T269 H272 R373 I187 F247 T270 H273 R374
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0046872 metal ion binding
Biological Process
GO:0006560 proline metabolic process
GO:0010133 proline catabolic process to glutamate
Cellular Component
GO:0009898 cytoplasmic side of plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4ns3, PDBe:4ns3, PDBj:4ns3
PDBsum4ns3
PubMed25557497
UniProtO50443

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