Structure of PDB 4nnd Chain D

Receptor sequence
>4nndD (length=281) Species: 9606 (Homo sapiens) [Search protein sequence]
DSARSFLERLEAVLAGEFSDIQACSAAWKADGVCSTVAGSRPENVRKNRY
KDVLPYDQTRVILSLLQEEHSDYINGNFIRGVDGSLAYIATQGPLPHTLL
DFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEPLQTGLFCITLIK
EKWLNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEE
ARRLQGSGPEPLCVHSSAGCGRTGVLCTVDYVRQLLLTQMIPPDFSLFDV
VLKMRKQRPAAVQTEEQYRFLYHTVAQMFCS
3D structure
PDB4nnd Large-scale structural analysis of the classical human protein tyrosine phosphatome.
ChainD
Resolution2.502 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D Y62 K63 D64 R140 D197 R198 S229 S230 A231 C233 R235 Q276 Y50 K51 D52 R127 D184 R185 S216 S217 A218 C220 R222 Q263
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4nnd, PDBe:4nnd, PDBj:4nnd
PDBsum4nnd
PubMed
UniProtQ99952|PTN18_HUMAN Tyrosine-protein phosphatase non-receptor type 18 (Gene Name=PTPN18)

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