Structure of PDB 4mvl Chain D

Receptor sequence
>4mvlD (length=171) Species: 9606 (Homo sapiens) [Search protein sequence]
LIPAPPLSKVPLQQNFQDNQFHGKWYVVGAAGNVLLREDKDPLKMYATIY
ELKEDKSYNVTSVGFDDKKCLYKIRTFVPGSQPGEFTLGRIKSEPGGTSW
LVRVVSTNYNQHAMVFFKEVAQNRETFNITLYGRTKELTSELKENFIRFS
KSLGLPENHIVFPVPIDQCID
3D structure
PDB4mvl High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer beta-amyloid peptide.
ChainD
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D L49 Y52 T54 S68 D72 L77 R81 L94 W106 F123 N134 Y138 P169 L43 Y46 T48 S62 D66 L71 R75 L88 W100 F117 N128 Y132 P163
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0036094 small molecule binding
GO:0042802 identical protein binding
GO:0140315 iron ion sequestering activity
GO:1903981 enterobactin binding
Biological Process
GO:0006826 iron ion transport
GO:0006915 apoptotic process
GO:0015891 siderophore transport
GO:0042742 defense response to bacterium
GO:0045087 innate immune response
GO:0120162 positive regulation of cold-induced thermogenesis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0031410 cytoplasmic vesicle
GO:0035580 specific granule lumen
GO:0060205 cytoplasmic vesicle lumen
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4mvl, PDBe:4mvl, PDBj:4mvl
PDBsum4mvl
PubMed27029347
UniProtP80188|NGAL_HUMAN Neutrophil gelatinase-associated lipocalin (Gene Name=LCN2)

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