Structure of PDB 4lzj Chain D

Receptor sequence
>4lzjD (length=297) Species: 727 (Haemophilus influenzae) [Search protein sequence]
LKSLSTLITEQRNPNSVDIDRQSTLEIVRLMNEEDKLVPLAIESCLPQIS
LAVEQIVQAFQQGGRLIYIGAGTSGRLGVLDASECPPTFGVSTEMVKGII
AGGECAIRHPVEGAEDNTKAVLNDLQSIHFSKNDVLVGIAASGRTPYVIA
GLQYAKSLGALTISIASNPKSEMAEIADIAIETIVGPEILTGSSRLKSGT
AQKMVLNMLTTASMILLGKCYENLMVDVQASNEKLKARAVRIVMQATDCN
KTLAEQTLLEADQNAKLAIMMILSTLSKSEAKVLLERHQGKLRNALS
3D structure
PDB4lzj Structure of MurNAc 6-phosphate hydrolase (MurQ) from Haemophilus influenzae with a bound inhibitor.
ChainD
Resolution2.405 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.2.1.126: N-acetylmuramic acid 6-phosphate etherase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO4 D R149 P151 R144 P146
BS02 22H D G77 R81 P115 E120 A145 A146 S147 T150 S199 R200 G72 R76 P110 E115 A140 A141 S142 T145 S194 R195 MOAD: Ki=0.23mM
Gene Ontology
Molecular Function
GO:0016803 ether hydrolase activity
GO:0016829 lyase activity
GO:0016835 carbon-oxygen lyase activity
GO:0097367 carbohydrate derivative binding
Biological Process
GO:0006040 amino sugar metabolic process
GO:0009254 peptidoglycan turnover
GO:0046348 amino sugar catabolic process
GO:0097173 N-acetylmuramic acid catabolic process
GO:0097175 1,6-anhydro-N-acetyl-beta-muramic acid catabolic process
GO:1901135 carbohydrate derivative metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4lzj, PDBe:4lzj, PDBj:4lzj
PDBsum4lzj
PubMed24251551
UniProtP44862|MURQ_HAEIN N-acetylmuramic acid 6-phosphate etherase (Gene Name=murQ)

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