Structure of PDB 4lz4 Chain D

Receptor sequence
>4lz4D (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQFG
3D structure
PDB4lz4 Dissecting the contribution of thrombin exosite I in the recognition of thrombin binding aptamer.
ChainD
Resolution2.56 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H43 D99 E202 G203 D204 S205 G206
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna D I24 R75 Y76 E77 R77A N78 I79 Y117 I9 R70 Y71 E72 R73 N74 I75 Y114
BS02 0G6 D H57 Y60A W60D L99 D189 A190 S195 S214 W215 G216 H43 Y47 W50 L96 D199 A200 S205 S226 W227 G228
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:4lz4, PDBe:4lz4, PDBj:4lz4
PDBsum4lz4
PubMed24128303
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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