Structure of PDB 4lrt Chain D

Receptor sequence
>4lrtD (length=293) Species: 471852 (Thermomonospora curvata DSM 43183) [Search protein sequence]
MGKAVAAIVGPGNIGTDLLIKLQRSEHIEVRYMVGVDPASEGLARARKLG
VEASAEGVDWLLEQDELPDLVFEATSAKAHLANAPRYAEAGITAIDLTPA
AVGPLVCPPVNLTEHLDAPNVNMITCGGQATIPIVHAVSRVVPVAYAEIV
AAIASRSAGPGTRANIDEFTETTAAAIEQVGGAARGKAIIILNPVEPPMI
MRDTVYCAIPPDADTDAITASIEEMVAEVARYVPGYTLRTEPQYDQPRDI
WKGMARVAVFLEVRGNGDYLPPWAGNLDIMTAAAARVGELLAQ
3D structure
PDB4lrt Crystal and solution structures of the bifunctional enzyme (Aldolase/Aldehyde dehydrogenase) from Thermomonospora curvata, reveal a cofactor-binding domain motion during NAD+ and CoA accommodation whithin the shared cofactor-binding site
ChainD
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.2.1.10: acetaldehyde dehydrogenase (acetylating).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA D P31 G32 N33 I34 G55 V56 S60 A94 T95 C146 T182 N296 L297 P11 G12 N13 I14 G35 V36 S40 A74 T75 C126 T162 N276 L277
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0008774 acetaldehyde dehydrogenase (acetylating) activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding
Biological Process
GO:0009056 catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4lrt, PDBe:4lrt, PDBj:4lrt
PDBsum4lrt
PubMed
UniProtD1A3K7

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