Structure of PDB 4loc Chain D

Receptor sequence
>4locD (length=596) Species: 347834 (Rhizobium etli CFN 42) [Search protein sequence]
DRATKLLTYLADVTVNGHPEAKDRPKPLENAARPVVPYANGNGVKDGTKQ
LLDTLGPKKFGEWMRNEKRVLLTDTTMRDGHQSLLATRMRTYDIARIAGT
YSHALPNLLSLECWGGATFDVSMRFLTEDPWERLALIREGAPNLLLQMLL
RGANGVGYTNYPDNVVKYFVRQAAKGGIDLFRVFDCLNWVENMRVSMDAI
AEENKLCEAAICYTGDILNSARPKYDLKYYTNLAVELEKAGAHIIAVKDM
AGLLKPAAAKVLFKALREATGLPIHFHTHDTSGIAAATVLAAVEAGVDAV
DAAMDALSGNTSQPCLGSIVEALSGSERDPGLDPAWIRRISFYWEAVRNQ
YAAFESDLKGPASEVYLHEMPGGQFTNLKEQARSLGLETRWHQVAQAYAD
ANQMFGDIVKVTPSSKVVGDMALMMVSQDLTVADVVSPREVSFPESVVSM
LKGDLGQPPSGWPEALQKKALKGEKPYTVRPGSLLKEADLDAERKVIEKK
LEREVSDFEFASYLMYPKVFTDFALASDTYGPVSVLPTPAYFYGLADGEE
LFADIEKGKTLVIVNQAVSATDSQGMVTVFFELNGQPRRIKVPDRA
3D structure
PDB4loc The role of biotin and oxamate in the carboxyltransferase reaction of pyruvate carboxylase.
ChainD
Resolution2.26 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D549 D655 K718 H747 H749 T882
Catalytic site (residue number reindexed from 1) D79 D185 K248 H277 H279 T412
Enzyme Commision number 6.4.1.1: pyruvate carboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D D549 K718 H747 H749 D79 K248 H277 H279
BS02 MG D M534 R535 E537 D768 M64 R65 E67 D298
BS03 BTN D Y479 D482 H488 P489 R1066 Y9 D12 H18 P19 R595
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004736 pyruvate carboxylase activity
GO:0005524 ATP binding
Biological Process
GO:0006090 pyruvate metabolic process
GO:0006094 gluconeogenesis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4loc, PDBe:4loc, PDBj:4loc
PDBsum4loc
PubMed25157442
UniProtQ2K340

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