Structure of PDB 4lgd Chain D

Receptor sequence
>4lgdD (length=338) Species: 9606 (Homo sapiens) [Search protein sequence]
LKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV
ESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDI
IRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRNIKAGNILLNTEGHA
KLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGIT
SIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLV
KNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQRELE
EEELDPMMEREIEELRQRYTAKRQPILDAMDAKKRRQQ
3D structure
PDB4lgd Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5.
ChainD
Resolution3.05 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N146 K148 G150 N151 D164 D173 T184
Catalytic site (residue number reindexed from 1) N136 K138 G140 N141 D154 D163 T174
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP D E35 G36 V41 K56 C102 D109 L153 D164 E25 G26 V31 K46 C92 D99 L143 D154
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:4lgd, PDBe:4lgd, PDBj:4lgd
PDBsum4lgd
PubMed23972470
UniProtQ13188|STK3_HUMAN Serine/threonine-protein kinase 3 (Gene Name=STK3)

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