Structure of PDB 4l6i Chain D

Receptor sequence
>4l6iD (length=286) Species: 6183 (Schistosoma mansoni) [Search protein sequence]
VKVGIIGGSGPNLFKKVGVRQVTTPFGKPSDTLVEGFVGDVACVVLPRHG
KGHLIPPSEVNYRANVWALKDLGCTHILATNACGSLQEDLVPGDFVVLNQ
FMDKTWGRENTFYGSKPDSLKGVLHMPMAEPFCERTRQILIQAARNKSIN
VYDKKTMDKSACIHPCVHAEGSAVTINGPRFSTRCESFIHKAMGLDIVNM
TLVPEVSLAREAGLSYASIAIVTDFDCWKSEEEHVCVDMVLEQFRKSVVH
VREILLEAVALIGAEDWTKTIEANKALVMSSRQDLL
3D structure
PDB4l6i Crystal Structure of Schistosoma mansoni Adenosine Phosphorylase/5'-Methylthioadenosine Phosphorylase and Its Importance on Adenosine Salvage Pathway.
ChainD
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) K34 H59 D230 D232
Catalytic site (residue number reindexed from 1) K28 H53 D224 D226
Enzyme Commision number 2.4.2.28: S-methyl-5'-thioadenosine phosphorylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADE D A88 C89 G90 F187 N205 T229 D230 D232 V246 A82 C83 G84 F181 N199 T223 D224 D226 V240
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0016757 glycosyltransferase activity
GO:0016763 pentosyltransferase activity
GO:0017061 S-methyl-5-thioadenosine phosphorylase activity
Biological Process
GO:0006166 purine ribonucleoside salvage
GO:0009116 nucleoside metabolic process
GO:0019509 L-methionine salvage from methylthioadenosine
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4l6i, PDBe:4l6i, PDBj:4l6i
PDBsum4l6i
PubMed27935959
UniProtI0B503

[Back to BioLiP]