Structure of PDB 4l3o Chain D

Receptor sequence
>4l3oD (length=293) Species: 9606 (Homo sapiens) [Search protein sequence]
RLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSNLEKYHLP
YPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLR
CYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKI
FSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTS
LQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKK
AYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQS
3D structure
PDB4l3o Structural Basis for Potent Inhibition of SIRT2 Deacetylase by a Macrocyclic Peptide Inducing Dynamic Structural Change
ChainD
Resolution2.518 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P94 D95 F96 R97 N168 D170 H187
Catalytic site (residue number reindexed from 1) P38 D39 F40 R41 N105 D107 H124
Enzyme Commision number 2.3.1.-
2.3.1.286: protein acetyllysine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D E116 E120 H187 V233 F235 G236 E237 S238 L239 F244 Q265 V266 Q267 P268 S271 D294 F296 G298 M299 M301 E53 E57 H124 V170 F172 G173 E174 S175 L176 F181 Q202 V203 Q204 P205 S208 D231 F233 G235 M236 M238
BS02 ZN D C195 C200 C221 C132 C137 C158
Gene Ontology
Molecular Function
GO:0017136 NAD-dependent histone deacetylase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:4l3o, PDBe:4l3o, PDBj:4l3o
PDBsum4l3o
PubMed24389023
UniProtQ8IXJ6|SIR2_HUMAN NAD-dependent protein deacetylase sirtuin-2 (Gene Name=SIRT2)

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