Structure of PDB 4koe Chain D

Receptor sequence
>4koeD (length=207) Species: 170187 (Streptococcus pneumoniae TIGR4) [Search protein sequence]
KLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAK
AKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHI
QTLLLTFFYRYMRPLVEAGHVYIALPPLYKYAWTDGELEELRKQQRYKGL
GEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWI
EDNVKFT
3D structure
PDB4koe Inhibitor-stabilised cleavage complexes of topoisomerase IIa: structural analysis of drug-dependent inter- and intramolecular interactions
ChainD
Resolution3.02 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna D D435 S436 D21 S22
BS02 dna D E433 G457 D510 E19 G43 D96
BS03 dna D K458 I460 N461 K464 N473 H513 R629 K44 I46 N47 K50 N59 H99 R196
BS04 MG D D506 D508 D92 D94
BS05 TR6 D R456 G457 E475 R42 G43 E61
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4koe, PDBe:4koe, PDBj:4koe
PDBsum4koe
PubMed
UniProtQ59961|PARE_STRPN DNA topoisomerase 4 subunit B (Gene Name=parE)

[Back to BioLiP]