Structure of PDB 4j5s Chain D

Receptor sequence
>4j5sD (length=140) Species: 9606 (Homo sapiens) [Search protein sequence]
RITYVKGDLFACPKTDSLAHCISEDCRMGAGIAVLFKKKFGGVQELLNQQ
KKSGEVAVLKRDGRYIYYLITKKRASHKPTYENLQKSLEAMKSHCLKNGV
TDLSMPRIGCGLDRLQWENVSAMIEEVFEATDIKITVYTL
3D structure
PDB4j5s Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease.
ChainD
Resolution1.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.-
3.5.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZZC D L24 C36 I37 G46 I47 K87 R122 G124 G126 L127 D128 L9 C21 I22 G31 I32 K72 R107 G109 G111 L112 D113
Gene Ontology
Molecular Function
GO:0001883 purine nucleoside binding
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0061463 O-acetyl-ADP-ribose deacetylase activity
GO:0140293 ADP-ribosylglutamate hydrolase activity
Biological Process
GO:0006974 DNA damage response
GO:0042278 purine nucleoside metabolic process
GO:0051725 protein de-ADP-ribosylation
GO:0140291 peptidyl-glutamate ADP-deribosylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0090734 site of DNA damage

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Molecular Function
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Cellular Component
External links
PDB RCSB:4j5s, PDBe:4j5s, PDBj:4j5s
PDBsum4j5s
PubMed23481255
UniProtQ9Y530|OARD1_HUMAN ADP-ribose glycohydrolase OARD1 (Gene Name=OARD1)

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