Structure of PDB 4iru Chain D

Receptor sequence
>4iruD (length=170) Species: 9606 (Homo sapiens) [Search protein sequence]
EYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELD
GKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESFNNVKQWL
QEIDRYASENVNKLLVGNKCDLTTKKVVDYTTAKEFADSLGIPFLETSAK
NATNVEQSFMTMAAEIKKRM
3D structure
PDB4iru The Legionella pneumophila GTPase Activating Protein LepB Accelerates Rab1 Deactivation by a Non-canonical Hydrolytic Mechanism.
ChainD
Resolution3.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q70
Catalytic site (residue number reindexed from 1) Q64
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG D S25 T43 S19 T37
BS02 GDP D G21 V22 G23 K24 S25 C26 Y36 N124 K125 D127 L128 S154 A155 K156 G15 V16 G17 K18 S19 C20 Y30 N118 K119 D121 L122 S148 A149 K150
BS03 AF3 D S20 K24 S42 T43 G69 Q70 S14 K18 S36 T37 G63 Q64
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:4iru, PDBe:4iru, PDBj:4iru
PDBsum4iru
PubMed23821544
UniProtP62820|RAB1A_HUMAN Ras-related protein Rab-1A (Gene Name=RAB1A)

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