Structure of PDB 4irq Chain D

Receptor sequence
>4irqD (length=243) Species: 9606 (Homo sapiens) [Search protein sequence]
EEDASWGPHRLAVLVPFRERFEELLVFVPHMRRFLSRKKIRHHIYVLNQV
DHFRFNRAALINVGFLESSNSTDYIAMHDVDLLPLNEELDYGFPEAGPFH
VASPELHPLYHYKTYVGGILLLSKQHYRLCNGMSNRFWGWGREDDEFYRR
IKGAGLQLFRPSGITTGYKTFRHLHDPAWRKRDQKRIAAQKQEQFKVDRE
GGLNTVKYHVASRTALSVGGAPCTVLNIMLDCDKTATPWCTFS
3D structure
PDB4irq Crystal structures of beta-1,4-galactosyltransferase 7 enzyme reveal conformational changes and substrate binding.
ChainD
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D163 D165 W224 E227 D228 T254 H257 H259
Catalytic site (residue number reindexed from 1) D79 D81 W140 E143 D144 T170 H173 H175
Enzyme Commision number 2.4.1.-
2.4.1.133: xylosylprotein 4-beta-galactosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN D D165 H257 H259 D81 H173 H175
BS02 UDP D P100 F101 R102 R104 F139 D163 V164 D165 Y194 H257 H259 R266 P16 F17 R18 R20 F55 D79 V80 D81 Y110 H173 H175 R182
Gene Ontology
Molecular Function
GO:0016757 glycosyltransferase activity
Biological Process
GO:0005975 carbohydrate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4irq, PDBe:4irq, PDBj:4irq
PDBsum4irq
PubMed24052259
UniProtQ9UBV7|B4GT7_HUMAN Beta-1,4-galactosyltransferase 7 (Gene Name=B4GALT7)

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