Structure of PDB 4i42 Chain D

Receptor sequence
>4i42D (length=268) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
IYPDEAMLYAPVEWHDCSEGFEDIRYEKSTDGIAKITINRPQVRNAFRPL
TVKEMIQALADARYDDNIGVIILTGAGDKAFCSGGDQKLNVLDFQRQIRT
CPKPVVAMVAGYSIGGGHVLHMMCDLTIAADNAIFGQTGPKVGSFDGGWG
ASYMARIVGQKKAREIWFLCRQYDAKQALDMGLVNTVVPLADLEKETVRW
CREMLQNSPMALRCLKAALNADCDGQAGLQELAGNATMLFYMTEEGQEGR
NAFNQKRQPDFSKFKRNP
3D structure
PDB4i42 Structural basis of the induced-fit mechanism of 1,4-dihydroxy-2-naphthoyl coenzyme A synthase from the crotonase fold superfamily
ChainD
Resolution1.848 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G86 L109 G133 V136 G156 S161 D163 G164 A250 Y258
Catalytic site (residue number reindexed from 1) G85 L92 G116 V119 G139 S144 D146 G147 A233 Y241
Enzyme Commision number 4.1.3.36: 1,4-dihydroxy-2-naphthoyl-CoA synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1HA D T254 F270 K273 T237 F253 K256
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0008935 1,4-dihydroxy-2-naphthoyl-CoA synthase activity
GO:0016829 lyase activity
GO:0071890 bicarbonate binding
Biological Process
GO:0009234 menaquinone biosynthetic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:4i42, PDBe:4i42, PDBj:4i42
PDBsum4i42
PubMed23658663
UniProtP0ABU0|MENB_ECOLI 1,4-dihydroxy-2-naphthoyl-CoA synthase (Gene Name=menB)

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