Structure of PDB 4hyp Chain D

Receptor sequence
>4hypD (length=194) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
GLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCKEIIVTIH
ADNSVSVQDDGRGIPTGIVSAAEVIMTVLHAGGKFKVSGGLHGVGVSVVN
ALSQKLELVIQREGKIHRQIYEHGVPQAPLAVTGETEKTGTMVRFWPSLE
TFTNVTEFEYEILAKRLRELSFLNSGVSIRLRDKRDGKEDHFHY
3D structure
PDB4hyp Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
ChainD
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1A1 D V43 N46 E50 D73 R76 G77 I78 P79 R140 T169 V29 N32 E36 D59 R62 G63 I64 P65 R112 T141
BS02 MG D E42 D45 V122 E28 D31 V94
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:4hyp, PDBe:4hyp, PDBj:4hyp
PDBsum4hyp
PubMed23352267
UniProtP0AES6|GYRB_ECOLI DNA gyrase subunit B (Gene Name=gyrB)

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