Structure of PDB 4hwk Chain D

Receptor sequence
>4hwkD (length=257) Species: 9606 (Homo sapiens) [Search protein sequence]
GLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAE
LGAERSGLRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGS
LGDVSKGFVDLSDSTQVNNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVV
NISSLCALQPFKGWALYCAGKAARDMLFQVLALEEPNVRVLNYAPGPLDT
DMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQKLLSLLEKDEFKSG
AHVDFYD
3D structure
PDB4hwk Tetrahydrobiopterin biosynthesis as an off-target of sulfa drugs.
ChainD
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.153: sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP D G11 S13 R14 G15 A38 R39 N40 D66 L67 N97 L123 I152 Y167 K171 P195 G196 P197 L198 T200 M202 G11 S13 R14 G15 A38 R39 N40 D66 L67 N97 L123 I152 Y167 K171 P195 G196 P197 L198 T200 M202
BS02 SFY D S154 L155 F161 W164 Y167 P197 S154 L155 F161 W164 Y167 P197 MOAD: ic50=82nM
Gene Ontology
Molecular Function
GO:0004033 aldo-keto reductase (NADPH) activity
GO:0004757 sepiapterin reductase (NADP+) activity
GO:0016491 oxidoreductase activity
GO:0050661 NADP binding
Biological Process
GO:0006729 tetrahydrobiopterin biosynthetic process
GO:0006809 nitric oxide biosynthetic process
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Cellular Component
External links
PDB RCSB:4hwk, PDBe:4hwk, PDBj:4hwk
PDBsum4hwk
PubMed23704574
UniProtP35270|SPRE_HUMAN Sepiapterin reductase (Gene Name=SPR)

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