Structure of PDB 4hlq Chain D

Receptor sequence
>4hlqD (length=170) Species: 9606 (Homo sapiens) [Search protein sequence]
EYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELD
GKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESYANVKQWL
QEIDRYASENVNKLLVGNKSDLTTKKVVDNTTAKEFADSLGIPFLETSAK
NATNVEQAFMTMAAEIKKRM
3D structure
PDB4hlq Catalytic mechanism of a mammalian Rab-RabGAP complex in atomic detail.
ChainD
Resolution3.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q67
Catalytic site (residue number reindexed from 1) Q64
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG D S22 T40 S19 T37
BS02 GDP D G18 V19 G20 K21 S22 C23 E35 N121 K122 D124 L125 A152 K153 G15 V16 G17 K18 S19 C20 E32 N118 K119 D121 L122 A149 K150
BS03 BEF D S17 K21 S22 T40 G66 S14 K18 S19 T37 G63
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:4hlq, PDBe:4hlq, PDBj:4hlq
PDBsum4hlq
PubMed23236136
UniProtQ9H0U4|RAB1B_HUMAN Ras-related protein Rab-1B (Gene Name=RAB1B)

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