Structure of PDB 4hk7 Chain D

Receptor sequence
>4hk7D (length=379) Species: 73501 (Cordyceps militaris) [Search protein sequence]
PVVVDIHTHMYPPSYIAMLEKRQTIPLVRTFPQADEPRLILLSSELAALD
AALADPAAKLPGRPLSTHFASLAQKMHFMDTNGIRVSVISLANPWFDFLA
PDEAPGIADAVNAEFSDMCAQHVGRLFFFAALPLSAPVDAVKASIERVKN
LKYCRGIILGTSGLGKGLDDPHLLPVFEAVADAKLLVFLHPHYGLPNEVY
GPRSEEYGHVLPLALGFPMETTIAVARMYMAGVFDHVRNLQMLLAHSGGT
LPFLAGRIESCIVHDGHLVKTGKVPKDRRTIWTVLKEQIYLDAVIYSEVG
LQAAIASSGADRLMFGTDHPFFPPIEEDVQGPWDSSRLNAQAVIKAVGEG
SSDAAAVMGLNAVRVLSLKAELEHHHHHH
3D structure
PDB4hk7 Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase.
ChainD
Resolution2.189 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.1.66: uracil-5-carboxylate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D H12 H14 H195 D323 H7 H9 H190 D318
BS02 ZN D H379 H384 H374 H379
BS03 URA D H14 R68 N98 H195 F222 D323 F326 H9 R63 N93 H190 F217 D318 F321
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0016831 carboxy-lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0019748 secondary metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4hk7, PDBe:4hk7, PDBj:4hk7
PDBsum4hk7
PubMed23917530
UniProtG3J531

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