Structure of PDB 4h0u Chain D

Receptor sequence
>4h0uD (length=254) Species: 196627 (Corynebacterium glutamicum ATCC 13032) [Search protein sequence]
TVPTPYEDLLRKIAEEGSHKDGTTSLFGQQIRFDLNEGFPLLTTKKVHFH
SVVGELLWFLQGDSNVKWLQDNNIRIWNEWADEDGELGPVYGVQWRSWPT
PDGRHIDQISGALETLRNNPDSRRNIVSAWNVSELENMALPPCHLLFQLY
VADGKLSCQLYQRSADMFLGVPFNIASYALLTHMFAQQAGLEVGEFIWTG
GDCHIYDNHKEQVAEQLSREARPYPTLELNKAASMFEYSFDDITVSGYDP
HPLI
3D structure
PDB4h0u Crystal structure of thymidylate synthase from Corynebacterium glutamicum in complex with dUMP
ChainD
Resolution2.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E61 W83 Y97 C149 R169 D172 P178
Catalytic site (residue number reindexed from 1) E55 W77 Y91 C143 R163 D166 P172
Enzyme Commision number 2.1.1.45: thymidylate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UMP D R129 R130 R123 R124
BS02 UMP D C149 R169 S170 D172 N180 H210 Y212 C143 R163 S164 D166 N174 H204 Y206
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0016741 transferase activity, transferring one-carbon groups
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4h0u, PDBe:4h0u, PDBj:4h0u
PDBsum4h0u
PubMed
UniProtQ8NS38|TYSY_CORGL Thymidylate synthase (Gene Name=thyA)

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