Structure of PDB 4gzt Chain D

Receptor sequence
>4gztD (length=388) Species: 119210 (H3N2 subtype) [Search protein sequence]
AEYRNWSKPQCDITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDPDKCYQ
FALGQGTTLNNVHSNNTVRGRTPYRTLLMNELGVPFHLGTKQVCIAWSSS
SCHDGKAWLHVCITGDDKNATASFIYNGRLVDSVVSWSKEILRTQESECV
CINGTCTVVMTDGSASGKADTKILFIEEGKIVHTSTLSGSAQHVEECSCY
PRYPGVRCVCRDNWKGSNRPIVDINIKDHSIVSSYVCSGLVGDTPRKNDS
SSSSHCLDPNNEEGGHGVKGWAFDDGNDVWMGRTINETSRLGYETFKVIE
GWSNPKSKLQINRQVIVDRGNRSGYSGIFSVEGKSCINRCFYVELIRGRK
EETEVLWTSNSIVVFCGTSGTYGTGSWPDGADLNLMPI
3D structure
PDB4gzt Influenza virus neuraminidases with reduced enzymatic activity that avidly bind sialic Acid receptors.
ChainD
Resolution2.19 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G151 E277 R292 R371 Y406
Catalytic site (residue number reindexed from 1) G70 E196 R211 R290 Y325
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BMA D Q391 I392 R394 Q310 I311 R313
BS02 FUC D N147 R150 N66 R69
BS03 G39 D R118 E119 R152 R224 R292 N294 R371 Y406 R37 E38 R71 R143 R211 N213 R290 Y325 MOAD: Ki=17nM
BS04 CA D D293 G297 D324 G345 H347 D212 G216 D243 G264 H266
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0046761 viral budding from plasma membrane
Cellular Component
GO:0016020 membrane
GO:0020002 host cell plasma membrane
GO:0033644 host cell membrane
GO:0044423 virion component
GO:0055036 virion membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4gzt, PDBe:4gzt, PDBj:4gzt
PDBsum4gzt
PubMed23015718
UniProtK7N5N3

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