Structure of PDB 4fj2 Chain D

Receptor sequence
>4fj2D (length=261) Species: 5503 (Curvularia lunata) [Search protein sequence]
TYIPGRLDGKVALVTGSGRGIGAAVAVHLGRLGAKVVVNYANSTKDAEKV
VSEIKALGSDAIAIKADIRQVPEIVKLFDQAVAHFGHLDIAVSNSGVVSF
GHLKDVTEEEFDRVFSLNTRGQFFVAREAYRHLTEGGRIVLTSSNTSKDF
SVPKHSLYSGSKGAVDSFVRIFSKDCGDKKITVNAVAPGGTVTDMFHEVS
HHYIPNGTSYTAEQRQQMAAHASPLHRNGWPQDVANVVGFLVSKEGEWVN
GKVLTLDGGAA
3D structure
PDB4fj2 Structural basis for inhibition of 17 beta-hydroxysteroid dehydrogenases by phytoestrogens: The case of fungal 17 beta-HSDcl.
ChainD
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G29 S153 N154 H164 Y167 K171 Y212
Catalytic site (residue number reindexed from 1) G20 S144 N145 H155 Y158 K162 Y203
Enzyme Commision number 1.1.1.62: 17beta-estradiol 17-dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP D G25 R28 G29 I30 A50 N51 S52 I77 N103 S104 G105 L126 T151 Y167 K171 G198 G199 T200 T202 M204 G16 R19 G20 I21 A41 N42 S43 I68 N94 S95 G96 L117 T142 Y158 K162 G189 G190 T191 T193 M195
BS02 QSO D V107 G199 F205 V208 Y212 V98 G190 F196 V199 Y203
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors

View graph for
Molecular Function
External links
PDB RCSB:4fj2, PDBe:4fj2, PDBj:4fj2
PDBsum4fj2
PubMed28259640
UniProtO93874

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