Structure of PDB 4f86 Chain D

Receptor sequence
>4f86D (length=273) Species: 324833 (Streptomyces lasalocidi) [Search protein sequence]
PATPYQEDIARYWNNEARPVNLRLGDVDGLYHHHYGIGAVDHAALGDPGY
EARLIAELHRLESAQAEFLLDHLGPVGPGDTLVDAGCGRGGSMVMAHQRF
GCKVEGVTLSAAQAEFGNRRARELGIDDHVRSRVCNMLDTPFEKGTVAAS
WNNESSMYVDLHDVFAEHSRFLRVGGRYVTVTGCWNPRYGQPSKWVSQIN
AHFECNIHSRREYLRAMADNRLVPQTVVDLTPETLPYWELRATSSLVTGI
EEAFIESYRDGSFQYVLIAADRV
3D structure
PDB4f86 Structure analysis of geranyl pyrophosphate methyltransferase and the proposed reaction mechanism of SAM-dependent C-methylation
ChainD
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.255: geranyl diphosphate 2-C-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SFG D W37 H57 H58 G113 G115 L136 Q140 N163 M164 N180 E181 S182 Y185 W13 H33 H34 G86 G88 L109 Q113 N136 M137 N153 E154 S155 Y158
BS02 GPP D W37 R42 N45 H57 Y59 E181 M184 F230 R268 F281 W13 R18 N21 H33 Y35 E154 M157 F203 R241 F254
BS03 MG D N45 E89 N21 E62
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0008168 methyltransferase activity
GO:0008169 C-methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:1904047 S-adenosyl-L-methionine binding
Biological Process
GO:0032259 methylation
GO:0042214 terpene metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4f86, PDBe:4f86, PDBj:4f86
PDBsum4f86
PubMed23090405
UniProtD3KYU3|GPPMT_STRLS Geranyl diphosphate 2-C-methyltransferase (Gene Name=gdpmt)

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