Structure of PDB 4f31 Chain D

Receptor sequence
>4f31D (length=258) Species: 10116 (Rattus norvegicus) [Search protein sequence]
RTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKL
SIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFS
KPFMSLGISIMIKKGTPIESAEDLAKQTEIAYGTLASGSTKEFFRRSKIA
VYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQR
KPCDTMKVGGNLDSKGYGVATPKGSALGNAVNLAVLKLNEQGLLDKLKNK
WWYDKGEC
3D structure
PDB4f31 The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation.
ChainD
Resolution2.286 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KAI D Y61 P89 L90 T91 R96 G141 S142 T143 E193 M196 Y58 P86 L87 T88 R93 G138 S139 T140 E190 M193 MOAD: Ki=2.08uM
BindingDB: EC50=40000nM,Ki=5780nM
BS02 ZN D E42 H46 E39 H43
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:4f31, PDBe:4f31, PDBj:4f31
PDBsum4f31
PubMed22512472
UniProtP19492|GRIA3_RAT Glutamate receptor 3 (Gene Name=Gria3)

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