Structure of PDB 4f2s Chain D

Receptor sequence

>4f2sD (length=583) Species: 235909 (Geobacillus kaustophilus HTA426) [Search protein sequence]

KPLAKMAFTLADRVTEEMLADKAALVVEVVEENYHDAPIVGIAVVNEHGR
FFLRPETALADPQFVAWLGDETKKKSMFDSKRAAVALKWKGIELCGVSFD
LLLAAYLLDPAQGVDDVAAAAKMKQYEAVRPDEAVYGKGAKRAVPDEPVL
AEHLVRKAAAIWELERPFLDELRRNEQDRLLVELEQPLSSILAEMEFAGV
KVDTKRLEQMGKELAEQLGTVEQRIYELAGQEFNINSPKQLGVILFEKLQ
LPVLKKTKTGYSTSADVLEKLAPYHEIVENILHYRQLGKLQSTYIEGLLK
VVRPATKKVHTIFNQALTQTGRLSSTEPNLQNIPIRLEEGRKIRQAFVPS
ESDWLIFAADYSQIELRVLAHIAEDDNLMEAFRRDLDIHTKTAMDIFQVS
EDEVTPNMRRQAKAVNYGIVYGISDYGLAQNLNISRKEAAEFIERYFESF
PGVKRYMENIVQEAKQKGYVTTLLHRRRYLPDITSRNFNVRSFAERMAMN
TPIQGSAADIIKKAMIDLNARLKEERLQAHLLLQVHDELILEAPKEEMER
LCRLVPEVMEQAVTLRVPLKVDYHYGSTWYDAK

3D structure

PDB

4f2s Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis.

Chain

Resolution

1.651 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	D	T550 K551 T552 T556 A558 R578 K582 Y587 R615 Q624 N625 I626 P627 I628 R629 H829	T257 K258 T259 T263 A265 R285 K289 Y294 R322 Q331 N332 I333 P334 I335 R336 H536
BS02	dna	D	N527 N529 S530 Q533 K582 S585 T586 T611 Q612 T613 S617 S618 T619 E620 N622 Y714 I716 S717 Y719 G720 R771 N782 F786 R789 Q797	N234 N236 S237 Q240 K289 S292 T293 T318 Q319 T320 S324 S325 T326 E327 N329 Y421 I423 S424 Y426 G427 R478 N489 F493 R496 Q504
BS03	GLC	D	E325 I605	E32 I312
BS04	FRU	D	D372 R375 D408 N607	D79 R82 D115 N314
BS05	CTP	D	Q656 E658 H682 R702 K706 Y710 Y714	Q363 E365 H389 R409 K413 Y417 Y421

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0008408	3'-5' exonuclease activity

	Biological Process
GO:0006139	nucleobase-containing compound metabolic process
GO:0006260	DNA replication
GO:0006261	DNA-templated DNA replication

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:4f2s, PDBe:4f2s, PDBj:4f2s
PDBsum	4f2s
PubMed
UniProt	Q5KWC1

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