Structure of PDB 4f0x Chain D

Receptor sequence
>4f0xD (length=445) Species: 9606 (Homo sapiens) [Search protein sequence]
GAMDELLRRAVPPTPAYELREAEGQCADFVSFYGGLAETAQRAELLGRLA
RGFGVDHGQVAEQSAGVLHLRQQQREAAVLLQAEDRLRYALVPRYRGLFH
HISKLDGGVRFLVQLRADLLEAQALKLVEGPDVREMNGVLKGMLSEWFSS
GFLNLERVTWHSPCEVLQKISEAEAVHPVKNWMDMKRRVGPYRRCYFFSH
CSTPGEPLVVLHVALTGDISSNIQAIVKEHPPSETEEKNKITAAIFYSIS
LTQQGLQGVELGTFLIKRVVKELQREFPHLGVFSSLSPIPGFTKWLLGLL
NSQTKNELFTDSECKEISEITGGPINETLKLLLSSSEWVQSEKLVRALQT
PLMRLCAWYLYGEKHRGYALNPVANFHLQNGAVLWRINWMADVSLRGITG
SCGLMANYRYFLEETGPNSTSYLGSKIIKASEQVLSLVAQFQKNS
3D structure
PDB4f0x Structural Asymmetry and Disulfide Bridges among Subunits Modulate the Activity of Human Malonyl-CoA Decarboxylase.
ChainD
Resolution3.29 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.1.9: malonyl-CoA decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0OR D I291 L293 G300 E302 S329 F422 H423 I249 L251 G258 E260 S287 F376 H377
Gene Ontology
Molecular Function
GO:0016831 carboxy-lyase activity
GO:0042802 identical protein binding
GO:0050080 malonyl-CoA decarboxylase activity
Biological Process
GO:0002931 response to ischemia
GO:0006085 acetyl-CoA biosynthetic process
GO:0006633 fatty acid biosynthetic process
GO:0006637 acyl-CoA metabolic process
GO:0007584 response to nutrient
GO:0010906 regulation of glucose metabolic process
GO:0019395 fatty acid oxidation
GO:0031998 regulation of fatty acid beta-oxidation
GO:0046320 regulation of fatty acid oxidation
GO:0046321 positive regulation of fatty acid oxidation
GO:2001294 malonyl-CoA catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4f0x, PDBe:4f0x, PDBj:4f0x
PDBsum4f0x
PubMed23482565
UniProtO95822|DCMC_HUMAN Malonyl-CoA decarboxylase, mitochondrial (Gene Name=MLYCD)

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