Structure of PDB 4ez6 Chain D

Receptor sequence

>4ez6D (length=580) Species: 235909 (Geobacillus kaustophilus HTA426) [Search protein sequence]

AKMAFTLADRVTEEMLADKAALVVEVVEENYHDAPIVGIAVVNEHGRFFL
RPETALADPQFVAWLGDETKKKSMFDSKRAAVALKWKGIELCGVSFDLLL
AAYLLDPAQGVDDVAAAAKMKQYEAVRPDEAVYGKGAKRAVPDEPVLAEH
LVRKAAAIWELERPFLDELRRNEQDRLLVELEQPLSSILAEMEFAGVKVD
TKRLEQMGKELAEQLGTVEQRIYELAGQEFNINSPKQLGVILFEKLQLPV
LKKTKTGYSTSADVLEKLAPYHEIVENILHYRQLGKLQSTYIEGLLKVVR
PATKKVHTIFNQALTQTGRLSSTEPNLQNIPIRLEEGRKIRQAFVPSESD
WLIFAADYSQIELRVLAHIAEDDNLMEAFRRDLDIHTKTAMDIFQVSEDE
VTPNMRRQAKAVNYGIVYGISDYGLAQNLNISRKEAAEFIERYFESFPGV
KRYMENIVQEAKQKGYVTTLLHRRRYLPDITSRNFNVRSFAERMAMNTPI
QGSAADIIKKAMIDLNARLKEERLQAHLLLQVHDELILEAPKEEMERLCR
LVPEVMEQAVTLRVPLKVDYHYGSTWYDAK

3D structure

PDB

4ez6 Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis.

Chain

Resolution

1.64 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	D	T550 K551 T552 T556 A558 R578 Y587 R615 Q624 N625 I626 P627 I628 R629 V828 H829 D830	T254 K255 T256 T260 A262 R282 Y291 R319 Q328 N329 I330 P331 I332 R333 V532 H533 D534
BS02	dna	D	N527 N529 S530 Q533 K582 S585 T586 T611 Q612 T613 R615 S617 S618 T619 E620 N622 G711 Y714 I716 S717 Y719 G720 R771 F786 R789 Q797	N231 N233 S234 Q237 K286 S289 T290 T315 Q316 T317 R319 S321 S322 T323 E324 N326 G415 Y418 I420 S421 Y423 G424 R475 F490 R493 Q501
BS03	DG3	D	R629 S655 Q656 E658 H682 R702 K706 Y710	R333 S359 Q360 E362 H386 R406 K410 Y414

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0008408	3'-5' exonuclease activity

	Biological Process
GO:0006139	nucleobase-containing compound metabolic process
GO:0006260	DNA replication
GO:0006261	DNA-templated DNA replication

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:4ez6, PDBe:4ez6, PDBj:4ez6
PDBsum	4ez6
PubMed
UniProt	Q5KWC1

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