Structure of PDB 4ewn Chain D

Receptor sequence
>4ewnD (length=243) Species: 2336 (Thermotoga maritima) [Search protein sequence]
LAKRIIACLDVKDGRVVKGTNFENLRDSGDPVELGKFYSEIGIDELVFLD
ITKTMLELVEKVAEQIDIPFTVGGGIHDFETASELILRGADKVSINTAAV
ENPSLITQIAQTFGSQAVVVAIVAKRVDGEFMVFTYSGKKNTGILLRDWV
VEVEKRGAGEILLTSIDRVGTKSGYDTEMIRFVRPLTTLPIIASGGAGKM
EHFLEAFLAGADAALAASVFHFREIDVRELKEYLKKHGVNVRL
3D structure
PDB4ewn A sugar isomerization reaction established on various (beta-alpha)8-barrel scaffolds is based on substrate-assisted catalysis
ChainD
Resolution1.903 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.3.2.10: imidazole glycerol-phosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0VR D V130 G177 S201 G202 G203 L222 A223 A224 S225 V123 G170 S194 G195 G196 L215 A216 A217 S218 MOAD: Kd=0.2uM
PDBbind-CN: -logKd/Ki=6.70,Kd=0.2uM
Gene Ontology
Molecular Function
GO:0000107 imidazoleglycerol-phosphate synthase activity
GO:0005515 protein binding
GO:0016829 lyase activity
Biological Process
GO:0000105 L-histidine biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:4ewn, PDBe:4ewn, PDBj:4ewn
PDBsum4ewn
PubMed23109729
UniProtQ9X0C6|HIS6_THEMA Imidazole glycerol phosphate synthase subunit HisF (Gene Name=hisF)

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