Structure of PDB 4enr Chain D

Receptor sequence
>4enrD (length=726) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
SLAPEDGSHRPAAEPTPPGAQPTAPGSLKAPDTRNEKLNSLEDVRKGSEN
YALTTNQGVRIADDQNSLRAGSRGPTLLEDFILREKITHFDHERIPERIV
HARGSAAHGYFQPYKSLSDITKADFLSDPNKITPVFVRFSTVQGGAGSAD
TVRDIRGFATKFYTEEGIFDLVGNNTPIFFIQDAHKFPDFVHAVKPEPHW
AIPQGQSAHDTFWDYVSLQPETLHNVMWAMSDRGIPRSYRTMEGFGIHTF
RLINAEGKATFVRFHWKPLAGKASLVWDEAQKLTGRDPDFHRRELWEAIE
AGDFPEYELGFQLIPEEDEFKFDFDLLDPTKLIPEELVPVQRVGKMVLNR
NPDNFFAENEQAAFHPGHIVPGLDFTNDPLLQGRLFSYTDTQISRLGGPN
FHEIPINRPTCPYHNFQRDGMHRMGIDTNPANYEPNSINDNWPRETPPGP
KRGGFESYQERVEGNKVRERSPSFGEYYSHPRLFWLSQTPFEQRHIVDGF
SFILSKVVRPYIRERVVDQLAHIDLTLAQAVAKNLGIELTDDQLNITPPP
DVNGLKKDPSLSLYAIPDGDVKGRVVAILLNDEVRSADLLAILKALKAKG
VHAKLLYSRMGEVTADDGTVLPIAATFAGAPSLTVDAVIVPCGNIADIAD
NGDANYYLMEAYKHLKPIALAGDARKFKATIKIADQGEEGIVEADSADGS
FMDELLTLMAAHRVWSRIPKIDKIPA
3D structure
PDB4enr Influence of main channel structure on H(2)O(2) access to the heme cavity of catalase KatE of Escherichia coli.
ChainD
Resolution1.6 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H128 N201 H392
Catalytic site (residue number reindexed from 1) H101 N174 H365
Enzyme Commision number 1.11.1.6: catalase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM D R125 I126 V127 H128 R165 V199 G200 N201 F206 F214 I274 H275 F391 L407 R411 S414 Y415 T418 Q419 R422 R98 I99 V100 H101 R138 V172 G173 N174 F179 F187 I247 H248 F364 L380 R384 S387 Y388 T391 Q392 R395
Gene Ontology
Molecular Function
GO:0004096 catalase activity
GO:0004601 peroxidase activity
GO:0005506 iron ion binding
GO:0020037 heme binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006972 hyperosmotic response
GO:0006974 DNA damage response
GO:0006979 response to oxidative stress
GO:0042744 hydrogen peroxide catabolic process
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4enr, PDBe:4enr, PDBj:4enr
PDBsum4enr
PubMed22820098
UniProtP21179|CATE_ECOLI Catalase HPII (Gene Name=katE)

[Back to BioLiP]