Structure of PDB 4e5h Chain D

Receptor sequence
>4e5hD (length=183) Species: 284218 (Influenza A virus (A/Viet Nam/1203/2004(H5N1))) [Search protein sequence]
MEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSD
GGSKHRFEIIEGRDRTMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIE
IGVTRREVHTYYLEKANKIKSEETHIHIFSFTGEEMATKADYTLDEESRA
RIKTRLFTIRQEMASRGLWDSFRQSERAAAELA
3D structure
PDB4e5h Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease.
ChainD
Resolution2.158 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN D H41 D108 E119 I120 H41 D89 E100 I101
BS02 MN D E80 P107 D108 E61 P88 D89
BS03 0N8 D Y24 H41 R84 W88 F105 L106 D108 E119 Y24 H41 R65 W69 F86 L87 D89 E100 MOAD: ic50=0.43uM
PDBbind-CN: -logKd/Ki=6.37,IC50=0.43uM
Gene Ontology
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:4e5h, PDBe:4e5h, PDBj:4e5h
PDBsum4e5h
PubMed22876176
UniProtQ5EP34

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