Structure of PDB 4e5f Chain D

Receptor sequence
>4e5fD (length=183) Species: 284218 (Influenza A virus (A/Viet Nam/1203/2004(H5N1))) [Search protein sequence]
MEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSD
GGSKHRFEIIEGRDRTMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIE
IGVTRREVHTYYLEKANKIKSEETHIHIFSFTGEEMATKADYTLDEESRA
RIKTRLFTIRQEMASRGLWDSFRQSERAAAELA
3D structure
PDB4e5f Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease.
ChainD
Resolution2.392 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN D H41 D108 E119 I120 H41 D89 E100 I101
BS02 MN D E80 P107 D108 E61 P88 D89
BS03 0N7 D H41 D108 E119 Y130 K134 H41 D89 E100 Y111 K115 MOAD: ic50=15uM
Gene Ontology
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:4e5f, PDBe:4e5f, PDBj:4e5f
PDBsum4e5f
PubMed22876176
UniProtQ5EP34

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