Structure of PDB 4dwj Chain D

Receptor sequence
>4dwjD (length=200) Species: 158878 (Staphylococcus aureus subsp. aureus Mu50) [Search protein sequence]
SAFITFEGPEGSGKTTVINEVYHRLVKDYDVIMTREPGGVPTGEEIRKIV
LEGNDMDIRTEAMLFAASRREHLVLKVIPALKEGKVVLCDRYIDSSLAYQ
GYARGIGVEEVRALNEFAINGLYPDLTIYLNVSAEVGRERIIKNSRDQNR
LDQEDLKFHEKVIEGYQEIIHQRFKSVNADQPLENVVEDTYQTIIKYLEK
3D structure
PDB4dwj Crystal structure of Thymidylate Kinase from Staphylococcus aureus in complex with Thymidine Monophosphate
ChainD
Resolution2.74 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.4.9: dTMP kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TMP D R36 F66 R70 R92 Y100 Q101 R35 F65 R69 R91 Y99 Q100
Gene Ontology
Molecular Function
GO:0004798 thymidylate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016597 amino acid binding
GO:0016743 carboxyl- or carbamoyltransferase activity
Biological Process
GO:0006227 dUDP biosynthetic process
GO:0006233 dTDP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0006520 amino acid metabolic process
GO:0009165 nucleotide biosynthetic process
GO:0016310 phosphorylation
GO:0046940 nucleoside monophosphate phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:4dwj, PDBe:4dwj, PDBj:4dwj
PDBsum4dwj
PubMed
UniProtP65248|KTHY_STAAM Thymidylate kinase (Gene Name=tmk)

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