Structure of PDB 4dd8 Chain D

Receptor sequence
>4dd8D (length=208) Species: 9606 (Homo sapiens) [Search protein sequence]
SRETRYVELYVVVDNAEFQMLGSEAAVRHRVLEVVNHVDKLYQKLNFRVV
LVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVD
FTGTTVGFARVSAMCSHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHD
ENVQGCRCQERFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVC
LANAPDLS
3D structure
PDB4dd8 Structure of human ADAM-8 catalytic domain complexed with batimastat.
ChainD
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BAT D T299 T300 V301 G302 H334 E335 H338 H344 G366 S367 T104 T105 V106 G107 H139 E140 H143 H149 G171 S172
BS02 CA D E203 D286 C395 N398 E8 D91 C200 N203
BS03 ZN D H334 H338 H344 H139 H143 H149
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4dd8, PDBe:4dd8, PDBj:4dd8
PDBsum4dd8
PubMed22684055
UniProtP78325|ADAM8_HUMAN Disintegrin and metalloproteinase domain-containing protein 8 (Gene Name=ADAM8)

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