Structure of PDB 4dcj Chain D

Receptor sequence
>4dcjD (length=141) Species: 9606 (Homo sapiens) [Search protein sequence]
DNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKY
EVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGP
VDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTEDDCGIET
3D structure
PDB4dcj Molecular insight into the role of the leucine residue on the L2 loop in the catalytic activity of caspases 3 and 7
ChainD
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T1062 S1063 H1121 G1122 C1163 R1164
Catalytic site (residue number reindexed from 1) T29 S30 H88 G89 C130 R131
Enzyme Commision number 3.4.22.56: caspase-3.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D R1064 H1121 Q1161 C1163 R31 H88 Q128 C130
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4dcj, PDBe:4dcj, PDBj:4dcj
PDBsum4dcj
PubMed22304005
UniProtP42574|CASP3_HUMAN Caspase-3 (Gene Name=CASP3)

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