Structure of PDB 4daj Chain D

Receptor sequence
>4dajD (length=432) Species: 10116,10665 [Search protein sequence]
WQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADL
IIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFD
RYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRT
VPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKMNIFE
MLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNTN
GVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQ
MGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRT
GTWDAYLIKEAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNL
GYWLCYINSTVNPVCYALCNKTFRTTFKTLLL
3D structure
PDB4daj Structure and dynamics of the M3 muscarinic acetylcholine receptor.
ChainD
Resolution3.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E1011 D1020
Catalytic site (residue number reindexed from 1) E206 D215
Enzyme Commision number 3.2.1.17: lysozyme.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0HK D D147 Y148 S151 N152 W199 W503 Y506 N507 Y529 C532 D83 Y84 S87 N88 W135 W376 Y379 N380 Y402 C405
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0004930 G protein-coupled receptor activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0009253 peptidoglycan catabolic process
GO:0016998 cell wall macromolecule catabolic process
GO:0031640 killing of cells of another organism
GO:0042742 defense response to bacterium
GO:0044659 viral release from host cell by cytolysis
Cellular Component
GO:0016020 membrane
GO:0030430 host cell cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4daj, PDBe:4daj, PDBj:4daj
PDBsum4daj
PubMed22358844
UniProtP00720|ENLYS_BPT4 Endolysin (Gene Name=E);
P08483

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