Structure of PDB 4d2v Chain D

Receptor sequence
>4d2vD (length=318) Species: 9606 (Homo sapiens) [Search protein sequence]
DYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLP
RIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQD
RLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFG
LCAKPKGNKGALAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFD
DDTAAALVAKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNH
PWIMQDYNYPVEWQSKFIHLDDDCVTELSVHHRNNRQTMISLWQYDHLTA
TYLLLLAKKARGKPVRLR
3D structure
PDB4d2v Fragment-Based Discovery of Type I Inhibitors of Maternal Embryonic Leucine Zipper Kinase
ChainD
Resolution2.45 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D132 K134 E136 N137 D150 A171
Catalytic site (residue number reindexed from 1) D130 K132 E134 N135 D148 A161
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 45R D I17 V25 A38 K40 E57 C70 L86 C89 I149 D150 I15 V23 A36 K38 E55 C68 L84 C87 I147 D148
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4d2v, PDBe:4d2v, PDBj:4d2v
PDBsum4d2v
PubMed25589925
UniProtQ14680|MELK_HUMAN Maternal embryonic leucine zipper kinase (Gene Name=MELK)

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