Structure of PDB 4d08 Chain D

Receptor sequence
>4d08D (length=335) Species: 9606 (Homo sapiens) [Search protein sequence]
KLLIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDC
PTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEI
FALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIA
ILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEV
GYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDL
EKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYE
RVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYE
3D structure
PDB4d08 Structure-Based Design of a Potent, Selective, and Brain Penetrating Pde2 Inhibitor with Demonstrated Target Engagement.
ChainD
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D H660 H696 D697 D808 H74 H110 D111 D222
BS02 Q2T D T768 D808 I826 M845 M847 Q859 F862 T182 D222 I240 M259 M261 Q273 F276 MOAD: ic50=10nM
BindingDB: IC50=10.0nM
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:4d08, PDBe:4d08, PDBj:4d08
PDBsum4d08
PubMed25221665
UniProtO00408|PDE2A_HUMAN cGMP-dependent 3',5'-cyclic phosphodiesterase (Gene Name=PDE2A)

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