Structure of PDB 4cvy Chain D

Receptor sequence
>4cvyD (length=235) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
LITVKKLGSRIGAQIDGVRLGGDLDPAAVNEIRAALLAHKVVFFRGQHQL
DDAEQLAFAGLLGTPINRWHTDVTFAANYPAASVLRAVSLPSYGGSTLWA
NTAAAYAELPEPLKCLTENLWALHTNDFRTEHPVVRVHPETGERTLLAGD
FVRSFVGLDSHESRVLFEVLQRRITMPENTIRWNWAPGDVAIWDNRATQH
RAIDDYDDQHRLMHRVTLMGDVPVDVYGQASRVIS
3D structure
PDB4cvy 2-Carboxyquinoxalines Kill Mycobacterium Tuberculosis Through Noncovalent Inhibition of Dpre1.
ChainD
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H97 D99 H251 R266
Catalytic site (residue number reindexed from 1) H70 D72 H200 R215
Enzyme Commision number 1.14.11.77: alkyl sulfatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE D H97 D99 H251 H70 D72 H200
Gene Ontology
Molecular Function
GO:0004065 arylsulfatase activity
GO:0016491 oxidoreductase activity
GO:0016706 2-oxoglutarate-dependent dioxygenase activity
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
Biological Process
GO:0046677 response to antibiotic
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4cvy, PDBe:4cvy, PDBj:4cvy
PDBsum4cvy
PubMed25427196
UniProtP9WKZ1|ATSK_MYCTU Alpha-ketoglutarate-dependent sulfate ester dioxygenase (Gene Name=Rv3406)

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